Support:Documents:Examples:Estimate Change of Neurotransmitter

Overview

The changes of endogenous neurotransmitter by PET scanning after a stimulus has been proved with different approaches. In stead of detecting the increase or decrease of neurotransmitter, it is important to characterize the temporal change of a neurotransmitter after a stimulus. Morris proposed the new technique for capturing the dynamic changes of a neurotransmitter after a stimulus and demonstrated the ability of this method to reconstruct the temporal characteistics of an enhance in neurotransmitter concentration.

Here we present a general model of ntPET, which can be simplified to Morris' model.

Generally, there are two separate PET scans: one for the rest condition (without any stimuli) and the other for the activation conditon (after a stimulus).