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COMKAT, which stands for 'COmpartment Model Kinetic Analysis Tool', is MATLAB software for compartmental modeling oriented to nuclear medicine applications (PET & SPECT). It supports models of a wide range complexity including multiple injection, receptor model with saturation. It supports many image formats, including DICOM images. Using either the command line interface or GUI, models are easily specified, solved or used to fit experimental data. Sensitivity equations are supported. No mathematical derivations are required on the part of the user.

Inside COMKAT

COMKAT serves as a bridge between biomedical imaging and modeling analysis. It can be divided into the following components:

• Command line functions

The command line functions of COMKAT provides functionalities to both imaging and modeling analysis. You can write a Matlab script to construct a compartment model with as simple as several lines. Models can be solved or used to estimate parameters. These functions are the basis of COMKAT because all the GUIs call underlying functions.

• COMKAT GUI

This GUI is designed for compartment modeling. Input and output can be loaded from various file formats. You may also set the output directly from images with COMKAT Image Tool. You can use the COMKAT GUI to fit experimental data and simply to simulate model output.

• COMKAT Image Tool

This GUI is designed for image display, fusion and region of interest. We support various image formats.

• COMKAT Input function GUI

To load input functions from files or functions, a user can use the input function GUI.

System requirement

Available version

COMKAT was originally designed to run as a Matlab toolbox. It can run as two modes now:

• Matlab mode

It is recommended that the users use COMKAT under Matlab.

• Standalone application mode

For those who does not have Matlab available, we have compiled COMKAT as a standalone executable now. Note: This would require Matlab Component Runtime (MCR)[1]. If you cannot obtain MCR, please contact us.

Operating system

COMKAT has been tested on Windows XP, MacOS 10.4 and Linux.

Matlab

We recommend using COMKAT under Matlab R14 or newer.