Publications:mainpage

How people use COMKAT

Peer-reviewed Articles

Before COMKAT's first public release

1. Muzic RF, Jr., Nelson AD, Saidel GM, Miraldi F. Optimal Experiment Design for PET Quantification of Receptor Concentration. IEEE Trans.Med.Imag. 1996;15:2-12.

2. Muzic RF, Saidel GM, Zhu N, Nelson AD, Zheng L, Berridge MS. Iterative Optimal Design of PET Experiments for Estimating b-Adrenergic Receptor Concentration. Med.& Biol.Engr.& Comput. 2000;38:593-602.

The seminal article

3. Muzic RF, Cornelius S. COMKAT: Compartment Model Kinetic Analysis Tool. J.Nucl.Med. 2001;42:636-645.

Since COMKAT's first public release

4. Yoder KK, Wang C, Morris ED. Change in binding potential as a quantitative index of neurotransmitter release is highly sensitive to relative timing and kinetics of the tracer and the endogenous ligand. J.Nucl.Med. 2004;45:903-911.

5. Morris ED, Christian BT, Yoder KK, Muzic RF, Jr. Estimation of local receptor density, B'max, and other parameters via multiple-injection positron emission tomography experiments. Methods Enzymol. 2004;385:184-213.

6. Christian BT, Narayanan T, Shi B, Morris ED, Mantil J, Mukherjee J. Measuring the in vivo binding parameters of [18F]-fallypride in monkeys using a PET multiple-injection protocol. J.Cereb.Blood Flow Metab 2004;24:309-322.

7. Pain F, Laniece P, Mastrippolito R, Gervais P, Hantraye P, Besret L. Arterial input function measurement without blood sampling using a beta-microprobe in rats. J.Nucl.Med. 2004;45:1577-1582.

8. Morris ED, Yoder KK, Wang C, et al. ntPET: a new application of PET imaging for characterizing the kinetics of endogenous neurotransmitter release. Mol.Imaging 2005;4:473-489.

9. Bingham EM, Dunn JT, Smith D, et al. Differential changes in brain glucose metabolism during hypoglycaemia accompany loss of hypoglycaemia awareness in men with type 1 diabetes mellitus. An [11C]-3-O-methyl-D-glucose PET study. Diabetologia 2005;48:2080-2089.

10. Yoder KK, Kareken DA, Seyoum RA, et al. Dopamine D(2) receptor availability is associated with subjective responses to alcohol. Alcohol Clin.Exp.Res. 2005;29:965-970.

11. Salinas CA, Muzic RF, Jr., Ernsberger P. PET Imaging of Myocardial B-Adrenergic Receptors with Fluorocarazolol: Lack of Interference by Endogenous Catecholamines. J.Cardiovasc.Pharmacol. 2005;

12. Muzic RF Jr, Christian BT. Evaluation of Objective Functions for Estimation of Kinetic Parameters. Med.Phys. 2006;33(2):342-53. PubMed

13. Christian BT, Lehrer DS, Shi B, et al. Measuring dopamine neuromodulation in the thalamus: using [F-18]fallypride PET to study dopamine release during a spatial attention task. Neuroimage. 2006;31:139-152.

14. Normandin MD, Morris ED. Temporal resolution of ntPET using either arterial or reference region-derived plasma input functions. Conf.Proc IEEE Eng Med.Biol.Soc. 2006;1:2005-2008.

15. Salinas CA., Muzic RF Jr., Saidel, GM. Validity of model approximations for receptor-ligand kinetics in nuclear medicine, Med Phys. 2007 May;34(5):1693-703. PubMed

16. Constantinescu CC, Bouman C, Morris ED. Nonparametric extraction of transient changes in neurotransmitter concentration from dynamic PET data. IEEE Trans.Med.Imaging 2007;26:359-373.

17. Morris ED, Yoder KK. Positron emission tomography displacement sensitivity: predicting binding potential change for positron emission tomography tracers based on their kinetic characteristics. J.Cereb.Blood Flow Metab 2007;27:606-617.

18. Salinas C, Muzic RF, Jr., Ernsberger P, Saidel GM. Robust experiment design for estimating myocardial beta adrenergic receptor concentration using PET. Med.Phys. 2007;34:151-165. PubMed

19. Saad A, Smith B, Hamarneh G, et al: Simultaneous segmentation, kinetic parameter estimation, and uncertainty visualization of dynamic PET images; Med Image Comput Comput Assist Interv Int Conf Med Image Comput Comput Assist Interv. 2007;10(Pt 2):726-33. PubMed

20. Landau BR, Spring-Robinson CL, Muzic RF, Jr., et al. 6-Fluoro-6-deoxy-D-glucose as a tracer of glucose transport. Am.J.Physiol Endocrinol.Metab 2007;293:E237-E245 Pubmed

21. Normandin MD, Morris ED. Estimating neurotransmitter kinetics with ntPET: a simulation study of temporal precision and effects of biased data. Neuroimage 2008;39:1162-1179.

22. Fang YH, Muzic RF, Jr. Spillover and Partial-Volume Correction for Image-Derived Input Functions for Small-Animal 18F-FDG PET Studies. J.Nucl.Med. 2008;49:606-614. PubMed

23. Constantinescu CC, Yoder KK, Kareken DA, et al. Estimation from PET data of transient changes in dopamine concentration induced by alcohol: support for a non-parametric signal estimation method. Phys.Med.Biol. 2008;53:1353-1367. PubMed

24. Morris ED, Normandin MD, Schiffer WK. Initial comparison of ntPET with microdialysis measurements of methamphetamine-induced dopamine release in rats: support for estimation of dopamine curves from PET data. Mol.Imaging Biol. 2008;10:67-73. PubMed

Manuscripts Under Review

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Abstracts

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Conference Proceedings

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Grants

1. Experimental Design for PET Receptor Models, PI: Raymond F. Muzic, Jr., Case Western Reserve University, Whitaker Foundation.

2. In Vivo Quantification of Heart Beta-Adrenergic Receptors, PI, Raymond F. Muzic, Jr., Case Western Reserve University, NIH R01 HL62399.

3. Quantitative FDG-PET for Imaging Woodchuck HCC, PI: Zhenghong Lee, Case Western Reserve University, NIH R01 CA095307.

4. COMKAT: Compartment Model Kinetic Analysis Tool for Quantitative Molecular Imaging, Case Western Reserve University, PI: Raymond Muzic, Jr., NIH R33 CA101073.

5. PET Evaluation of Hemorrhagic Shock and Resuscitation, PI: Vibhudutta Awasthi, University of TX Health Science Center at San Antonio, NIH R21/R33 EB005187.

6. Temporal Response of Dopamine to Alcohol Imaged via PET, PI: Evan D Morris, Indiana University, NIH R21 AA015077-01A2.