Difference between revisions of "Support:Documents:Examples:Estimate Change of Neurotransmitter"
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Generally, there are two separate scans for ntPET: one for the rest condition (without any stimuli) and the other for the activation conditon (after a stimulus). | Generally, there are two separate scans for ntPET: one for the rest condition (without any stimuli) and the other for the activation conditon (after a stimulus). | ||
| − | + | C<sub>p</sub> is the pasma concentration of tracer for the first scan (the "rest" condtion), F is free (unbound) tracer and B is bound tracer. C<sub>p2</sub> is the pasma concentration of tracer for the second scan (the "activation" condtion), F2 is free (unbound) tracer and B2 is bound tracer. F<pub>en</pub> and B(en) are free and bound by endogenous ligand. | |
| + | == Headline text == | ||
| + | |||
===Implementing the Compartment Model=== | ===Implementing the Compartment Model=== | ||
==Create a new model for ntPET== | ==Create a new model for ntPET== | ||
Revision as of 18:45, 25 February 2009
Model of Neurotransmitter PET (ntPET)
Overview
The changes of endogenous neurotransmitter by PET scanning after a stimulus has been proved with different approaches. In stead of detecting the increase or decrease of a neurotransmitter, it is important to characterize the temporal change of a neurotransmitter after a stimulus. Morris proposed the new technique (called ntPET) for capturing the dynamic changes of a neurotransmitter after a stimulus and demonstrated the ability of this method to reconstruct the temporal characteistics of an enhance in neurotransmitter concentration.
Here we present a general model of ntPET, which can be simplified to Morris' model.
Generally, there are two separate scans for ntPET: one for the rest condition (without any stimuli) and the other for the activation conditon (after a stimulus). Cp is the pasma concentration of tracer for the first scan (the "rest" condtion), F is free (unbound) tracer and B is bound tracer. Cp2 is the pasma concentration of tracer for the second scan (the "activation" condtion), F2 is free (unbound) tracer and B2 is bound tracer. F<pub>en</pub> and B(en) are free and bound by endogenous ligand.