Difference between revisions of "Support:Documents:Examples:Estimate Change Neurotransmitter"

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== Estimating Input Delay and Rate Constants ==
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== Estimate neurotransmitter of PET (ntPET) imaging==
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This example demonstrates an approach to simultaneously estimating input function delay along with parameters of the 1-tissue compartment (e.g. blood flow) model.
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Underwork
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For the sake of generality, this could be interpreted as a dynamic contrast-enhanced (DCE) MRI or perfusion PET study.
 
  
  
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==== Tissue uptake ====
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==== Background====
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This model has one tissue compartment.  Material in the blood is assumed to rapidly exchange with that in (extravascular) tissue.
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Underwork
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The tissue model has two rate constants: K<sub>1</sub> and k<sub>2</sub> and is depicted in the diagram:
 
  
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==== Input function ====
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==== Kinetic model of ntPET ====
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This example also demonstrates how to temporally align measured input function data to the tissue (image) data.  Here the plasma concentration vs. time t is modeled as
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Underwork
  
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== Example:  Estimating Input Delay and Rate Constants ==
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== Examples==
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Latest revision as of 23:43, 23 February 2009

Estimate neurotransmitter of PET (ntPET) imaging

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Background

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Kinetic model of ntPET

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Examples

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